AI-Powered Malaria Control: Diptera.ai Reaches Field-Validation Milestone

[Photo: Dr. Eli Ordan and Dr. Ariel Livne, co-founders of Diptera.ai, alongside Dr. Filipos Papathanos of the Hebrew University. Courtesy of Diptera.ai]

Diptera.ai’s flagship project has reached a major breakthrough. After three years of intensive development—and in partnership with the BIRD Foundation, which supports industrial collaboration between Israel and the United States—the Israeli company has completed a full end-to-end system based on the Sterile Insect Technique (SIT), a biological method for mosquito control that relies on releasing sterilized males.

The project delivered a complete operational chain for Anopheles mosquitoes, including rearing, sorting, sterilization, marking, and AI-driven monitoring. The system was subsequently validated on live mosquito populations in Kenya and a second African country. With each technological milestone now achieved, Diptera.ai is preparing for the next step: widescale field trials across Sub-Saharan Africa.

The company was founded in response to the urgent global need to curb the spread of malaria, a disease that kills hundreds of thousands each year. Traditional control methods are losing effectiveness, while SIT offers a clean, targeted alternative that avoids chemical pesticides. Historically, large-scale SIT deployment has been constrained by the inability to sort larvae at high throughput, the lack of reliable training data for AI models, and insufficient real-time monitoring tools.

Diptera.ai has now removed these bottlenecks. The company developed optical-imaging systems capable of detecting sex organs in larvae, a water-flow mechanism for processing large volumes, and a fully automated AI pipeline that generates high-quality labeled datasets without manual intervention. In partnership with U.S.-based Vectech, the team also created the Scout trap—equipped with UV illumination and machine-vision algorithms—to identify marked mosquitoes in the field and map population dynamics in real time.

During the project, the work expanded to additional major Anopheles species, including gambiae and coluzzii, significantly increasing market impact. All components—rearing, sorting, sterilization, and field hardware—were re-engineered, tested, and adapted to local conditions in semi-natural African facilities. Results demonstrate full technological readiness: near-perfect larval sex-sorting accuracy, 97% precision in detection models, and reliable field monitoring through the Scout platform.

Diptera.ai is now targeting initial deployments in multiple African countries, in collaboration with governments, researchers, and global health organizations. Beyond the technological achievement, the company views this milestone as a foundation for a systemic shift in how malaria is fought—moving mosquito control toward a fully automated, data-driven, AI-enabled discipline.

Dr. Eli Ordan, Diptera.ai co-founder, said:
“The support of the BIRD Foundation is instrumental in accelerating our joint effort with Vectech to combat the growing threat of malaria in Sub-Saharan Africa. This cross-border collaboration allows us to merge advanced AI-driven monitoring with cutting-edge vector-control technologies, creating a scalable solution for malaria prevention. BIRD’s involvement is not only a vote of confidence in the urgency of the mission, but also a catalyst that helps transform scientific innovation into real-world impact.”

Omer Carmel, Director of Business Development at the BIRD Foundation, added:
“BIRD’s investment and guidance in this project highlight our commitment to breakthrough technologies capable of addressing critical global challenges such as malaria prevention. Working with Diptera.ai and Vectech enabled us to support AI-based solutions that deliver tangible results in the field, demonstrating BIRD’s role as a bridge for groundbreaking collaboration between Israeli and American companies.”

Israeli Zzapp is determined to eradicate malaria in Africa

The Israeli start-up company Zzapp-Malaria, which has developed an AI-based platform for locating high-risk areas for malaria outbreaks based on satellite images and data from other sources, aims to demonstrate the technology it has developed to help eradicate malaria.

The company, which recently won first place in the prestigious international competition of Xprize sponsored by IBM Watson, intends to dedicate the prize money, about $ 3 million, to carry out a targeted eradication campaign of malaria in one of the African countries

In an interview with Techtime, the company’s founder and CEO, Arnon Khoury-Yafin, explained that the success of such an operation could change the way the fight against the plague is been executed. ” For several years now, the malaria morbidity curve has been on the plain, not rising but also not falling. We want to defeat the disease and show that it can be eradicated using the right means. That is why we want to focus on one country and show that it is possible, similar to the way Israel was a pilot for the Pfizer company that demonstrated the effectiveness of the Covid-19 vaccines. ”

To eradicate the disease ‘the good old way’

Malaria is a parasitic disease transmitted by Anopheles mosquitoes, one of the deadliest diseases known to mankind. About half of the world’s population lives in areas at risk of contracting malaria, of which hundreds of millions are infected and sick, and more than 400,000 people die from it each year – most of them children under the age of 5. Pregnant women are another group at particular risk. About 95% of malaria deaths occur in Africa.
However, malaria can be eradicated by treating the water sources in which mosquitoes breed – many countries have done so, and the pioneers in Israel were among the first to do so. In tropical Africa, however, these operations are difficult to plan, manage and monitor.

Zazapp Malaria has set itself the goal of enabling such eradication operations. The technology is based on artificial intelligence that Zzapp has developed using satellite images alongside rainfall and topography data to map districts, villages, and water sources. For each village, the system simulates thousands of possible action strategies and recommends the best. The app has been used in 6 African countries and has been shown to increase the number of water resources treated, save time, and significantly improve operations effectiveness.

The company is soon expected to publish the results of a pilot it conducted in Ghana. The company’s flagship project is a planned operation in the island state of Sao Tome and Principe off the west coast of Africa, where the ambitious goal is the complete eradication of malaria in less than a year. The company collaborates with the International Health Organization, the Bill and Melinda Gates Foundation, research bodies, associations, and local government bodies.

Zzapp, which was established in 2017, is a subsidiary of Sight Diagnostics. Yafin-Khoury says that the vision behind the establishment of Zazapp was born during his work at Sight. “Sight developed tests to diagnose malaria. I witnessed the great suffering of malaria patients. I came to the company’s board and asked to set up a company that would focus on eradicating the disease, and they gave me their blessing.”

[Pictured above: Zzapp Malaria Team]